GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs774359 | 1 | rs774356 | chr9:27559721 | C9orf72 | chr9:27546544-27573842:- | 0.41 | 5.6 | 2.04E-7 | Amyotrophic lateral sclerosis |
| THYM | cis | rs774359 | 1 | rs774359 | chr9:27561049 | C9orf72 | chr9:27546544-27573842:- | 0.4 | 5.45 | 3.94E-7 | Amyotrophic lateral sclerosis |
| THYM | cis | rs2143950 | 1 | rs77477310 | chr14:35615793 | KIAA0391 | chr14:35591776-35786673:+ | 0.35 | 4.67 | 9.73E-6 | Atopic dermatitis |
| THYM | cis | rs2143950 | 1 | rs77477310 | chr14:35615793 | PPP2R3C | chr14:35554679-35591679:- | 0.26 | 4.92 | 3.68E-6 | Atopic dermatitis |
| THYM | cis | rs1577917 | 1 | rs7747824 | chr6:86647106 | SNHG5 | chr6:86386726-86388451:- | -0.58 | -7.77 | 9.26E-12 | Response to antipsychotic treatment |
| THYM | cis | rs9473555 | 1 | rs7750918 | chr6:49430082 | MUT | chr6:49398994-49431031:- | 0.29 | 4.41 | 2.7E-5 | Folate pathway vitamin levels |
| THYM | cis | rs1577917 | 1 | rs7756203 | chr6:86627707 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |
| THYM | cis | rs9369898 | 1 | rs7759071 | chr6:49433198 | CENPQ | chr6:49431096-49460820:+ | -0.3 | -5.72 | 1.22E-7 | Homocysteine levels |
| THYM | cis | rs1577917 | 1 | rs7760207 | chr6:86721700 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |
| THYM | cis | rs7969151 | 1 | rs77658252 | chr12:54156208 | COPZ1 | chr12:54718911-54745633:+ | -0.3 | -4.54 | 1.64E-5 | Tanning |
| THYM | cis | rs1577917 | 1 | rs7766645 | chr6:86622238 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -7.62 | 1.9E-11 | Response to antipsychotic treatment |
| THYM | cis | rs1577917 | 1 | rs7771342 | chr6:86631936 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |
| THYM | cis | rs73726531 | 1 | rs7773076 | chr6:18107132 | NHLRC1 | chr6:18120718-18122851:- | -1.06 | -4.36 | 3.24E-5 | Thiopurine S-methyltransferase activity |
| THYM | cis | rs9369898 | 1 | rs7774688 | chr6:49387292 | CENPQ | chr6:49431096-49460820:+ | -0.3 | -5.65 | 1.67E-7 | Homocysteine levels |
| THYM | cis | rs73726531 | 1 | rs7775626 | chr6:18144521 | NHLRC1 | chr6:18120718-18122851:- | -1.05 | -4.61 | 1.24E-5 | Thiopurine S-methyltransferase activity |